1916 – 1948:

Dr A Kerr, M.A., M.P.C

1949 – 1955:

Prof CP Dent, M.SC. (S.A)

1955 – 1959:

Acted as Principal – Prof HR Burrows M.COM, M.C., E.D.

1959 – 1968:

Prof JJ Roos, B.A.(SA), BSc (SA), H.S.E.D. (Stell), BEd (SA), M.A. (Yale), LLB (UOFS), B. Admin (UOFS).

1968 – 1981:

Prof JM de Wet, MSc (SA), BSc ENG (WITS), DIC PhD (London)

1981 – 1991:

Prof JA Lamprecht, BA (WITS), B.D. (London), D.D. (London)

1991 – 1992:

Acted as Vice-Chancellor – Prof JB Gardner, B.Com (UCT), Med (UPE), CA (SA)

1993 – 1994:

Prof SME Bengu, BA (UNIZUL), BA (Hons) (UNISA), PhD (Pol Sci) (Geneva), D.D. (Dubuque USA)

1995 – 1998:

Prof MV Mzamane, MA (UBLS), PhD (Sheffield)

1999 – 2007:

Prof DI Swartz, BA (UWC), MA, PhD (Essex)

2008-2016 :

Prof ME Tom, MB CHB (Natal), M Fam Med (Wits) M Sc Public Policy & Management (University of London)